1. the largest city in Missouri; a busy river port on the Mississippi River near its confluence with the Missouri River; was an important staging area for wagon trains westward in the 19th century • Syn: St. Louis, Gateway to the West • Instance Hypernyms: city, metropolis, urban center, port • Part Holonyms: Missouri, Show Me State, MO 2. king of France and son of Louis VIII; he led two unsuccessful Crusades; considered an ideal medieval king (1214-1270) • Syn: Louis IX, St. Louis • Instance Hypernyms: King of France, saint