1. a port city in southeastern Cuba; industrial center • Syn: Santiago • Instance Hypernyms: city, metropolis, urban center, port • Part Holonyms: Cuba, Republic of Cuba 2. a naval battle in the Spanish-American War (1898); the United States fleet bottled up the Spanish ships in the harbor of Santiago de Cuba and destroyed them when they tried to escape • Syn: Santiago • Regions: Cuba • Instance Hypernyms: naval battle • Part Holonyms: Spanish-American War, Spanish War